function indices of the uterus and ovary of cyclophosphamide-induced gonadal toxicity in female Wistar rats. A total of 36 female rats assigned randomly to six groups of six animals were treated for 21 days. Group 1 received only distilled water. Groups 2 – 6 were treated with a single dose (200 mgkg-1 body weight) of cyclophosphamide intraperitoneally and in addition, received the same volume (0.5 ml) of distilled water, 18, 36, 72 mgkg-1 body weight of the extract and 200 mgkg-1 body weight of vitamin C orally. Findings indicated that cyclophosphamide significantly (p < 0.05) increased the blood concentrations of follicle stimulating hormone, luteinizing hormone, and prolactin but contrarily reduced ((p < 0.05) the concentration of estrogen and progesterone. In addition, the uterine and ovarian activities/levels of acid and alkaline phosphatases, 3- β-hydroxysteroid dehydrogenase, 17-β-hydroxysteroid dehydrogenase, cholesterol, glucose; superoxide dismutase, catalase, glutathione reductase, and glutathione-S- transferase were significantly (p < 0.05) reduced by cyclophosphamide. Meanwhile, cyclophosphamide increased (p < 0.05) the activity of myeloperoxidase as well as the concentrations of TNF-α and interleukin 6. On the contrary, the extract reversed the action of cyclophosphamide to level that compared well with the control (p < 0.05). Furthermore, the treatment-related histoarchitectural changes in the ovary and uterus of the female rats caused by cyclophosphamide were reversed by the extract. Put together, leaf extract of B. patula demonstrated the ability to reverse damages to the ovaries and uterus and thus can be explored as a safe agent against toxic side effects of chemotherapy and fertility- related malady of the uterus and ovary.