The significance of pathoanatomical studies concerning diseases that impact wild animals cannot be overstated, as
they serve as a fundamental pillar in facilitating the implementation of effective measures for the prevention and control of these afflictions. The challenges of cases of mortality in wildlife may be isolated cases from government-owned facilities and educational centers but it is important to put together some of these cases of wildlife mortality especially as it concerns private zoos. This case report aimed at presenting the post-mortem findings of four cases of mortality in two (2) private zoological gardens in Nigeria. The post-mortem findings showed evidence of sand colic in zebra, helminthosis in a hippopotamus, electric shock in a chimpanzee, and acute mortality syndrome in a giraffe. These findings underscore the need for holistic intervention and veterinary care in the management of zoological gardens especially in low-resource settings.